Cyclins D2 and D3 expression in de novo CD5-positive and CD5-negative DLBCLs. Cyclin D2 expression in de novo CD5-positive (A, B, and C) and CD5-negative (D, E, and F) DLBCLs, H&E staining (A &D), cyclin D2 staining (B &E), and cyclin D3 staining (C &F) (×400). Cyclin D2 staining was frequently localized to both the nucleus and the cytoplasm in the de novo CD5-positive DLBCLs (B). Cyclin D3 showed a crisp nuclear staining pattern in both CD5-positive and negative DLBCLs (C &F).
Igawa et al. Diagnostic Pathology 2013 8:81 doi:10.1186/1746-1596-8-81