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Open Access Research

De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression

Takuro Igawa1, Yasuharu Sato1*, Katsuyoshi Takata1, Noriko Iwaki1, Takehiro Tanaka2, Naoko Asano3, Yoshinobu Maeda4, Yorihisa Orita5, Naoya Nakamura6, Shigeo Nakamura7 and Tadashi Yoshino1

Author Affiliations

1 Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan

2 Department of Pathology, Okayama University Hospital, Okayama, Japan

3 Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan

4 Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

5 Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan

6 Department of Pathology, Tokai University School of Medicine, Isehara, Japan

7 Department of Pathology, Nagoya University Hospital, Nagoya, Japan

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Diagnostic Pathology 2013, 8:81  doi:10.1186/1746-1596-8-81

Published: 15 May 2013

Abstract

D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1382856320966453 webcite

Keywords:
Cyclin D2; CD5; Diffuse large B-cell lymphoma