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Open Access Case Report

Primary angiosarcoma of the breast: a case report

Amal Bennani1*, Layla Chbani1, Meryem Lamchahab1, Mouhcine Wahbi2, Fatimazzahra Fdili Alaoui2, Ikram Badioui1, Moulay Abdelilah Melhouf2 and Affaf Amarti1

Author Affiliations

1 Department of Pathology, HASSAN II University Hospital, Fez 30000, Morocco

2 Department of Gynecology and Obstetrics, HASSAN II University Hospital, Fez 30000, Morocco

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Diagnostic Pathology 2013, 8:66  doi:10.1186/1746-1596-8-66

Published: 22 April 2013

Abstract

Primary angiosarcoma of the breast is extremely rare. Radiologic findings are often non specific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastasis. Surgical removal followed by adjuvant chemotherapy seems improve the prognosis.

We report a case of a 33- year-old woman with a highly vascular mass in her right breast which is suggestive of malignancy at radiology. Initial core needle biopsy showed a benign hemangioma. The patient underwent a mastectomy. The tumor histology showed papillary formations and vascular structures lined by atypical cells with hyperchromatic nucleus and eosinophilic cytoplasm with solid areas. The tumor cells expressed CD34 and CD31 but were negative for cytokeratin. The diagnosis of angiosarcoma grade III was made. The patient is now receiving chemotherapy. She is still alive.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1530481200889780 webcite