A juvenile case of conjunctival atypical nevus
1 Pathology Unit, Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande, CT, Italy
2 Gecas srl, Via San Paolo 68, Gravina di Catania, CT, Italy
3 Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Viale GB Morgagni 85, Florence, Italy
4 Division of Pathology, CRO - Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Via Franco Gallini 2, Aviano, PN, Italy
Diagnostic Pathology 2013, 8:64 doi:10.1186/1746-1596-8-64Published: 22 April 2013
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2973228795724608 webcite
Melanocytic nevi are the most common tumors of the conjunctiva, accounting for 28% of all neoplastic lesions. These tumors, despite their benign behavior, share some atypical histological features with nevi found in other anatomic sites like the genital and acral regions, globally designated as nevi with site-related atypia. Moreover, in children and adolescents, rapidly growing conjunctival nevi show sometimes worrisome histological patterns in association with a prominent inflammatory infiltrate that may lead to diagnostic problems. In this paper we describe a juvenile compound nevus characterized by marked melanocytic atypia and severe inflammation, which can be considered a rare case of juvenile conjunctival atypical nevus. The final diagnosis relied on morphological and immunohistochemical characterization of the large epithelioid melanocytic cells, and on the results of FISH analysis.