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Open Access Case Report

Primary pulmonary primitive neuroectodermal tumor metastasis to the pancreas: a rare case with seven-year follow-up

Lin Shi12, Zhanlin Guo3* and Xinlin Wu4

Author affiliations

1 Department of Pathology, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, 010059, China

2 Institute of pathology and pathophysiology, Inner Mongolia Medical University, Huhhot, 010059, China

3 Department of Cardiovascular and Thoracic Surgery, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia, 010059, P. R. China

4 Department of General Surgery, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, 010059, China

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Citation and License

Diagnostic Pathology 2013, 8:51  doi:10.1186/1746-1596-8-51

Published: 27 March 2013

Abstract

There are only nine primitive neuroectodermal tumor (PNET) cases that have arisen in lung parenchyma without pleural or chest wall involvement in the literature. Here, we present a long–term survival case of pulmonary PNET. A pulmonary mass was detected in a 19-year-old man on a chest radiograph and computed tomography image. At the three-year follow-up, the mass had enlarged in diameter by two-fold. The lesion was resected via lower left lobectomy. Histologically, the tumor was composed of uniform cells with round nuclei and scanty cytoplasm arranged in lobules with rosettes and pseudorosettes formation. Immunohistochemically, the tumor was positive for CD99, vimentin, neuron specific enolase and chromogranin A, and negative for cytokeratins, CD3, desmin, and leukocyte common antigen. Pancreatic metastasis occurred sixteen months after the first surgery, which was managed by pancreatectomy. The patient has survived seven years after the mass was initially detected, and four years after the first lobectomy.

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1500847644913244 webcite

Keywords:
Primitive neuroectodermal tumor; Lung; Metastasis; Pancreas