Representative FISH image of neuroblastic tumor cells displaying MYCN gene status. A: Amplification:The number of MYCN signals (green) is more than 10 copies of the CEP2 probe signals (red). B: Gain:The number of MYCN signals (green) is 1 copy greater than the CEP2 probe signals; C: No Alteration: Cells with MYCN signals (green) showing the same numbers of the CEP2 probe signals. (DAPI counterstain, original magnification ×1000).
Wang et al. Diagnostic Pathology 2013 8:5 doi:10.1186/1746-1596-8-5