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A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature

Merieme Ghaouti1*, Kaoutar Znati1, Ahmed Jahid1, Fouad Zouaidia1, Zakiya Bernoussi1, Youssef El Fakir2 and Najat Mahassini1

Author Affiliations

1 Department of Pathology, Ibn Sina Univesity Hospital, Rabat, Morocco

2 Nakhil Radiology Center, Rabat, Morocco

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Diagnostic Pathology 2013, 8:4  doi:10.1186/1746-1596-8-4

Published: 10 January 2013


Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case of gallbladder polypoid tumor revealing metastatic clear cell renal cell carcinoma, which demonstrates the importance of radiological tests, histology and immunohistochemistry when making a definitive diagnosis. These examinations also allow differentiating metastatic clear cell renal cell carcinoma from other polypoid lesions in the gallbladder with clear cell morphology. Cholecystectomy should be performed to obtain a definitive diagnosis and to improve survival in case of solitary metastatic renal cell carcinoma.

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Kidney tumors; Clear cell renal cell carcinoma; Gallbladder metastasis; Cholecystectomy