Schematic representation of promotion function of DEC1 in cell proliferation. DEC1 is inducible by HIF-1α in cancer cell. The mechanism of this interaction has been shown to be the HIF-1α/β complex directly binding to the HIF-1 binding site in the hypoxia response element(HRE) of the DEC1 promoter to initiate the transcription of DEC1.The cells that lack the functional tumor suppressor von Hippel-Lindau(VHL) express higher levels of DEC1. DEC1 is a downstream target of transforming growth factor β signaling, which promotes the survival of cells. DEC1 transcriptionally upregulates the expression of the survivin and signal transducer and activator of transcription 3 (STAT3). Forced expression of DEC1 selectively inhibits the activation of procaspases.
Jia et al. Diagnostic Pathology 2013 8:37 doi:10.1186/1746-1596-8-37