Table 1

Comparison of immunohistochemical markers between adjacent normal mucosa, tubular adenomas and RCT
Table 1 Pure RCT (case I) Composite RCT (case II)
Markers NM1 RC NM2 TA CTA GC RC
CK20 +++ neg. +++ +++ +++ + neg.
CK7 neg neg. neg. neg. neg. neg. neg.
CDX2 +++ neg. +++ +++ +++ + neg.
E-cadherin ++ neg. ++ ++ ++ + neg.
β-catenina (a) + + + + + ++ neg.
APC (c-ter) ++ ++ ++ ++ +++ ++ ++
p53 neg. ++ neg. + +++ ++ +
Vimentin neg. +++ neg. neg neg. ++ +++
CK18 + + + ++ ++ + ++
CK19 ++ ++ ++ ++ ++ + ++
CK-Pan +++ ++ +++ +++ +++ +++ +++
HDAC1 + +++ + + ++ ++ +++
HDAC2 + +++ + + ++ ++ +++
HDAC3 + +++ + + ++ ++ +++
VEGFR1 neg. neg. neg. + + neg. neg.
VEGFR2 neg. +++ neg. neg. neg. ++ ++
MLH1 +++ neg. +++ ++ ++ neg. neg.
MSH2 +++ + ++ ++ ++ ++ ++
TS + + + ++ ++ + +
INI1 + +++ + + ++ + neg.

(+++): widespread occurrence, intense expression; (++): Varying distribution, moderate expression; (+): Limited occurrence, low expression; (−) no occurrence or negative. aβ-catenin nuclear localization; Abbreviations: Cytokeratin, CK; pure rhabdoid colorectal tumor, case I (RCTI); glandular (GC) and rhabdoid (RC) components of composite rhabdoid colorectal tumor, case II (RCTII); adjacent tubular adenomas (TA), cancerized and larger tubular adenoma (CTA) or normal mucosa (NM2) of case II. Case I, a pure RCT, is compared to the adjacent distant non-neoplastic mucosa (NM1); histone deacetylase, HDAC; vascular endothelial growth factor receptors, VEGFR; thymidylate synthase, TS.

Pancione et al.

Pancione et al. Diagnostic Pathology 2013 8:31   doi:10.1186/1746-1596-8-31

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