Open Access Open Badges Case Report

Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma

Maki Kanzawa1*, Chihoko Hirai1, Yukiko Morinaga2, Fumi Kawakami1, Shigeo Hara1, Hiroshi Matsuoka3 and Tomoo Itoh1

Author Affiliations

1 Department of Diagnostic Pathology, Kobe University Hospital, Hyogo, Japan

2 Department of Diagnostic Pathology, Osaka Medical Center, Osaka, Japan

3 Department of internal medicine, division of medical oncology/hematology, Kobe University Hospital, Hyogo, Japan

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Diagnostic Pathology 2013, 8:30  doi:10.1186/1746-1596-8-30

Published: 20 February 2013


Gastric plasmacytoma (GP) is a rare variant of gastric lymphomas. In the exceptional event that a patient presents with GP, the lesion occupies the mucosal layer in the vast majority of cases. Here we report a case of nodular plasmacytoma confined to the submucosa with no evidence of Helicobacter pylori (Hp) infection. The patient was a 59-year old female presenting with no particular symptoms. The tumor was well-demarcated and consisted of a diffuse monomorphic proliferation of plasma cells with numerous lymphoid follicles scattered throughout the tumor. The mucosal surface was intact and not associated with any tumor nodules. The cells were diffusely positive for CD79a, Bob1, EMA and IgA and consistently negative for CD3, CD19, CD20, PAX5, CD56, IgM and IgG. Additionally, in situ hybridization demonstrated clonality in the form of λ light-chain restriction. This submucosal nodular proliferation pattern of plasmacytoma is poorly recognized and considered to be a novel variant of lymphoma.

The virtual slide(s) for this article can be found here: webcite

Plasmacytoma; Solitary; Stomach; Submucosa; Lymphoma