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Open Access Highly Accessed Case Report

Pulmonary metastasis of a papillary thyroid carcinoma and primary lung adenocarcinoma: two coincident carcinomas at the same location

Liyan Xue1, Zhonghua Luan12, Ying Liu3, Shuangmei Zou1, Jun Jiang4, Ning Wu34, Ning Lu1* and Dongmei Lin1*

Author Affiliations

1 Department of Pathology, Cancer Institute (Hospital), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

2 Department of Pathology, Yuncheng Central Hospital, Yuncheng, Shanxi Province, China

3 Department of Nuclear Medicine, Cancer Institute (Hospital), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

4 Department of Imaging Diagnosis, Cancer Institute (Hospital), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

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Diagnostic Pathology 2013, 8:26  doi:10.1186/1746-1596-8-26

Published: 16 February 2013

Abstract

Tumor-to-tumor metastasis is a fairly rare phenomenon. The lung cancers are the most common donors, but are exceedingly rare as recipients. Here we report a case of a lung adenocarcinoma acting as the recipient of papillary thyroid carcinoma, with multiple spreading foci of the two cancers in the lung simultaneously. The morphology and immunohistochemisty (Napsin-A, Thyroglobulin) are very important in differential diagnosis of lung primary adenocarcinoma and metastatic papillary thyroid carcinoma.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2069496615891134 webcite

Keywords:
Tumor-to-tumor metastasis; Papillary thyroid carcinoma; Lung adenocarcinoma; Napsin-A; Thyroglobulin