Case 2 possessing EIC in both endometrial polyp and endometrium (A. Pap × 20, B. Pap × 60, C. loupe view, D. HE × 20, E. HE × 60, F. HE × 60). A. Papillary-structured carcinoma cell cluster is accompanied by a watery background (Pap. ×20). B. The N/C ratio is fairly high and the chromatin is coarsely granular (Pap. ×60). C. Loupe findings show an endometrial polyp arising in the uterine fundus, measuring 1.5 cm in longitudinal length. The endometrium is markedly thin and atrophic. The area marked by an arrow and that marked by an arrowhead are depicted respectively in E and F. D. In the polyp, the glands composed of carcinoma cells are found to be aggregated in the fibrotic stroma. E. Carcinoma cells are replacing the glands in the polyp and stratified into micropapillary protrusions, lacking apparent stromal invasion (HE × 20). F. Carcinoma nests similar to those in the endometrial polyp (D) are also present in the endometrial gland (HE × 60).
Yasuda et al. Diagnostic Pathology 2013 8:25 doi:10.1186/1746-1596-8-25