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Open Access Highly Accessed Research

Accumulation of Fascin+ cells during experimental autoimmune neuritis

Zichen Yang1, Jian Sun1, Xiaofeng Yang1, Zhiyuan Zhang2, Bangwei Lou1, Jian Xiong1, Hermann J Schluesener2 and Zhiren Zhang1*

Author Affiliations

1 Institute of Immunology, Third Military Medical University of PLA, 30 Gaotanyan Main Street, Chongqing 400038, People’s Republic of China

2 Division of Immunopathology of the Nervous System, University of Tuebingen, Calwer Street 3, Tuebingen D-72076, Germany

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Diagnostic Pathology 2013, 8:213  doi:10.1186/1746-1596-8-213

Published: 25 December 2013

Abstract

Background

Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles.

Methods

Here we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats.

Results

A robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN.

Conclusion

Our results suggest a pathological role of Fascin in EAN.

Virtual slides

The virtual slides for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/6734593451114811 webcite

Keywords:
EAN; Fascin; Dendritic cells