P27 protein was expressed in the cytoplasm and nuclei of non-cancerous and malignant epithelial cells and its down-regulation was indicated in NPC tissues compared to NP samples (original magnifications are: Х 100). A shows the strong expression of p27 in normal epithelium; and in some cases, p27 highly expresses in cytoplasm and nucleus (inset); B displays the high p27 expression in cytoplasm and nuclei of NPC tissues; C shows the positive cytoplasm p27 expression in NPC tissues; D indicates the negative expression of p27 in NPC tissues.(insets showing P27 expression observed under high magnification Х 400).
Jiang et al. Diagnostic Pathology 2013 8:212 doi:10.1186/1746-1596-8-212