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Histological subtypes and characteristic structures of HPV-associated oropharyngeal carcinoma; study with Japanese cases

Mitsuhisa Fujimaki1, Yuki Fukumura2*, Keiko Mitani2, Aiko Kurisaki2, Junkichi Yokoyama1, Katsuhisa Ikeda1 and Takashi Yao2

Author Affiliations

1 Department of Otorhinolaryngology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

2 Department of Human Pathology, Juntendo University School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

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Diagnostic Pathology 2013, 8:211  doi:10.1186/1746-1596-8-211

Published: 19 December 2013

Abstract

Background

Human papillomavirus-associated oropharyngeal carcinoma (HPV-OPC) is clinicopathologically distinct entity from the HPV-unassociated one (nHPV-OPC). This study aimed to determine the relationship between histological subtypes of OPC and HPV status for Japanese cases and to identify histological structures of HPV-OPC.

Methods

66 OPC cases were categorized into conventional squamous cell carcinoma (SCC) and the variants. Conventional SCC was subcategorized into keratinizing (KSCC), non-keratinizing (NKSCC), and hybrid SCC (HSCC). HPV status of all cases was determined using p16-immunohistochemistry and HPV-DNA ISH.

Results

Two histological subtypes, NKSCC and HSCC, tended to be HPV-OPC and KSCC tended to be nHPV-OPC with statistical significance. Two histological structures, abrupt keratinization, defined in the text, and comedo-necrosis among non-maturing tumor island, were observed for 58.1% and 38.7% of HPV-OPC, and tended to exist for HPV-OPC with statistical significance.

Conclusions

This study showed the association of NKSCC/HSCC with HPV-OPC in Japanese cases, and two histological structures, abrupt keratinization and comedo-necrosis among non-maturing island, were considered characteristic histological features of HPV-OPC.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1816432541113073 webcite.

Keywords:
Human papillomavirus-associated oropharyngeal carcinoma; Non-keratinizing squamous cell carcinoma; Abrupt keratinization; Comedo-necrosis among non-maturing island