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Open Access Highly Accessed Case Report

Early detection of colon cancer by amino acid profiling using AminoIndex Technology: a case report

Junichi Yatabe12*, Midori Sasaki Yatabe2, Katsuyuki Ishibashi3, Yoshihiro Nozawa4 and Hironobu Sanada56

Author Affiliations

1 Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan

2 Department of Pharmacology, Fukushima Medical University School of Medicine, Fukushima, Japan

3 Department of Gastrointestinal Medicine, Bange Kosei General Hospital, Fukushima Welfare Federation of Agricultural Cooperatives, Fukushima, Japan

4 Department of Pathology, Shirakawa Kosei General Hospital, Fukushima Welfare Federation of Agricultural Cooperatives, Fukushima, Japan

5 Department of Tumor and Host Bioscience, Fukushima Medical University School of Medicine, Fukushima, Japan

6 Division of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Fukushima, Japan

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Diagnostic Pathology 2013, 8:203  doi:10.1186/1746-1596-8-203

Published: 10 December 2013

Abstract

Most tumor markers have low detection rates for curable stages of cancer and are therefore not satisfactory for use in a healthy population. A new cancer risk calculation method, AminoIndex Cancer Screening (AICS), uses multiple plasma amino acid concentrations to calculate the risks for several cancers simultaneously and is suggested to have a high detection rate for early-stage cancers and a low false-positive rate for adenomas. Here, we describe a male patient with a family history of colorectal cancer who underwent AICS. He was judged as Rank C for colorectal cancer, which reportedly has a specificity of 95%, a sensitivity of 41%, and an estimated positive predictive value of 0.67%. He underwent colonoscopy for a secondary screening, which revealed a 10-mm adenoma-like lesion in the ascending colon, with a biopsy report of partial carcinoma. The tumor was endoscopically removed and diagnosed as carcinoma in situ (carcinoma in adenoma). This early detection method allowed complete resection of the carcinoma, and the patient is in remission. This is the first case in which a curable cancer was detected using AICS. With its high detection rate for early-stage cancers and its ease of use, this tool, which recently became available in Japan, may be beneficial for simultaneous screening of the general population for multiple cancers.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2145080259887842 webcite

Keywords:
Plasma amino acid; Colorectal cancer; Adenoma; AminoIndex Cancer Screening