Patterns of PRMT5 expression in surgically resected lung tumors. Cytoplasmic PRMT5 is seen diffusely throughout a tumor (a-c) while nuclear expression varies (b-c); squamous cell carcinoma (a-b); small cell lung carcinoma (c); immunohistochemistry, original magnification ×200, ×600, and ×600, respectively. A distinct nuclear accumulation of PRMT5 forming varying in size intranuclear globules is seen in squamous cell carcinoma, arrows (b); in contrast, nuclear accumulation of PRMT5 in small cell lung carcinoma is finely granular, arrowheads (c). No PRMT5 expression is seen in alveolar parenchyma away from tumors (d), immunohistochemistry, original magnification ×400.
Shilo et al. Diagnostic Pathology 2013 8:201 doi:10.1186/1746-1596-8-201