Immunohistochemical staining for EndoMT-related markers in the surgical SCC lesion after sclerotherapy. (A) The continuous expression of CD34 (endothelial cells) of the vessels within residual VMs was obviously damaged. (B) Strong expression of α-SMA (smooth muscle cells) around the vessels within residual VMs, or even invaded across the endothelial layers to fill the venous lumen. (C) Positive nuclear location of slug in the inner layer of the vessels within residual VMs (D, magnification).
Chen et al. Diagnostic Pathology 2013 8:182 doi:10.1186/1746-1596-8-182