Table 2

Main meta-analysis results
Analysis No. of studies No. of patients HR (95% CI) p value Model Heterogeneity Publication bias
I2 (%) p Begg’s p Egger’s p
Overall survival (OS) 8 2615 1.90 (1.58–2.29) < 0.001 F 0.0 0.48 0.06 0.03
Subgroup 1: treatment
  Surgery 6 1922 2.27 (1.74–2.96) < 0.001 F 0.0 0.68 0.26 0.27
  surgery + chemotherapy 2 693 1.60 (1.24–2.07) < 0.001 F 0.0 1.00 - -
Subgroup 2: type of method used to obtain the HR
  Reported HR 6 2167 1.89 (1.53–2.35) < 0.001 F 23.3 0.26 0.13 0.06
  Calculated HR 2 448 1.92 (1.34–2.74) < 0.001 F 0.0 0.89 - -
Subgroup 3: study regions
  Asia 5 1213 2.08 (1.55–2.80) < 0.001 F 0.0 0.83 0.09 0.07
  Europe 2 951 2.18 (1.11–4.28) 0.02 R 72.8 0.06 - -
  Australia 1 451 1.6 (1.10–2.20) 0.008 - - - - -
Disease-free survival (DFS) 3 950 2.16 (1.53–3.05) < 0.001 F 0.0 0.667 1.000 0.825
Clinicopathological parameters OR (95% CI)
  Age (old vs. young) 7 2040 1.24 (0.99–1.56) 0.06 F 0.0 0.91 1.00 0.87
  Gender (female vs. man) 7 2113 1.15 (0.93–1.43) 0.21 F 23.2 0.25 1.00 0.81
  Tumor location (rectum vs. colon) 6 1662 1.34 (1.06–1.69) 0.01 F 0.0 0.97 0.71 0.57
  Differentiation (poorly vs. well and moderately) 7 1340 1.04 (0.75–1.44) 0.80 F 0.0 0.61 0.55 0.22
  Lymph node metastasis (yes vs. no) 6 1671 2.62 (1.40–4.90) 0.003 R 83.7 0.00 0.26 0.07
  Nodal status (N1 ~ 2 vs. N0) 4 1230 2.68 (1.57–4.55) < 0.001 R 59.9 0.06 0.09 0.02
  Distant metastasis (M1 vs. M0) 3 768 3.22 (0.65–15.84) 0.15 R 75.6 0.02 1.00 0.17
  TNM stage (III/IV vs. I/II) 5 1732 3.03 (1.48–6.20) 0.002 R 82.4 0.00 0.81 0.20
  Tumor depth (T 3/4 vs. T 1/2) 6 1922 1.82 (1.35–2.46) < 0.001 F 0.0 0.49 0.71 0.99
  Tumor size (size ≥ 5 cm vs. < 5 cm) 6 1523 0.88 (0.67–1.16) 0.37 F 0.0 0.48 1.00 0.99
  Vascular invasion (yes vs. no) 2 977 1.29 (0.83–2.03) 0.26 F 0.0 0.48 - -
  Recurrence (yes vs. no) 2 335 2.03 (0.87–4.73) 0.100 R 68.2 0.076 - -

HR = hazard ratio Model; OR = Odds ratio; CI = confidence interval; F = fixed-effects model; R = random-effects model.

Liu et al.

Liu et al. Diagnostic Pathology 2013 8:181   doi:10.1186/1746-1596-8-181

Open Data