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Open Access Open Badges Case Report

Sclerosing rhabdomyosarcoma presenting in the masseter muscle: a case report

Xu-Yong Lin12, Yan Wang12, Juan-Han Yu12, Yang Liu12, Liang Wang12, Qing-Chang Li12 and En-Hua Wang12*

Author Affiliations

1 Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang 110001, China

2 Institute of pathology and pathophysiology, China Medical University, Shenyang 110001, China

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Diagnostic Pathology 2013, 8:18  doi:10.1186/1746-1596-8-18

Published: 4 February 2013


Sclerosing rhabdomyosarcoma (SRMS) is exceedingly rare, and may cause a great diagnostic confusion. Histologically, it is characterized by abundant extracellular hyalinized matrix mimicking primitive chondroid or osteoid tissue. So, it may be easily misdiagnosed as chondrosarcoma, osteosarcoma, angiosarcoma and so on. Herein, we report a case of SRMS occurring in the masseter muscle in a 40-year-old male. The tumor showed a diverse histological pattern. The tumor cells were arranged into nests, cords, pseudovascular, adenoid, microalveoli and even single-file arrays. Immunostaining showed that the tumor was positive for the Vimentin, Desmin and MyoD1, and was negative for CK, P63, NSE, CD45, CD30, S-100, CD99, Myoglobin, CD68, CD34, CD31, and α–SMA. Based on the morphological finding and immunostaining, it was diagnosed as a SRMS. In addition, focally, our case also displayed a cribriform pattern resembling adenoid cystic carcinoma. This may represent a new histological feature which can broaden the histological spectrum of this tumor and also may lead to diagnostic confusion.

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Sclerosing rhabdomyosarcoma; Rhabdomyosarcoma; Sarcoma