Table 7

Prognostic value of clinicopathological factors and copy number variation of mtDNA in univariate and multivariate Cox regression analysis (n=103)
Univariate analysis Multivariate analysis
Variable Hazard ratio (95% CI) P Hazard ratio (95% CI) P
Copy number
3.61~5.35 1.00 (reference) 1.00 (reference)
<3.61 1.51 (0.44-2.57) 0.90 0.52 (0.20-1.38) 0.19
>5.35 1.53 (0.58-4.02) 0.39 1.07 (0.37-3.07) 0.90
The number of lymph node metastasis
0 1.00 (reference) 1.00 (reference)
1~6 6.86 (3.18-14.91) <0.001 7.28 (2.87-18.49) <0.001
7~15 6.41 (2.70-15.25) <0.001 4.68 (1.65-13.28) 0.004
≥16 16.75 (5.05-55.56) <0.001 13.21 (3.33-52.45) <0.001
Tumor invasion
T1 1.00 (reference) 1.00 (reference)
T2 0.85 (0.16-4.67) 0.86 0.63 (0.11-3.54) 0.60
T3 4.36 (1.53-12.42) 0.006 1.51 (0.46-4.92) 0.49
T4 2.66 (1.30-5.48) 0.001 3.33 (0.92-12.14) 0.07
Differentiation
Well/moderate 1.00 (reference) 1.00 (reference)
Poor/undifferentiation 2.22 (1.19-4.19) 0.01 1.82 (0.86-3.82) 0.12

Zhang et al.

Zhang et al. Diagnostic Pathology 2013 8:173   doi:10.1186/1746-1596-8-173

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