The effect of variable mtDNA content on poor survival of gastric cancer patients. Kaplan-Meier analysis of survival was performed according to copy number variations of mtDNA in a large cohort of gastric cancers. Kaplan-Meier survival curves show that variable (decreased or increased) mtDNA content was not associated with overall survival of the patients. However, when the data were stratified further based on the TNM tumor stage, increased mtDNA content (>5.35 copies) was strongly associated with worse survival in the patients who had late-stage tumors.
Zhang et al. Diagnostic Pathology 2013 8:173 doi:10.1186/1746-1596-8-173