Photomicrographs of hematoxylin-eosin staining and immunohistochemistry. (a,b) Several cells with moderately large oval clear nuclei mimicking ganglioglioma (arrow) and eosinophilic spindle cells with small dark nucleus (arrowhead) were also observed. The large oval nuclei have marked nucleolar (arrow). These lesions were diffusely and strongly positive for (c) synaptophysin and (d) neuronal nuclear antigen. The cells stained positively for (e) tubulin, βIII isoform and (f) neurofilament in a spotty pattern. (g) On the other hand, spindle cells were positive for GFAP. (h) Silver impregnation staining revealed no desmoplasia. (a-g: ×400; h: ×100).
Yano et al. Diagnostic Pathology 2013 8:164 doi:10.1186/1746-1596-8-164