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Case report: Papillary mesothelioma of the peritoneum with foamy cell lining

Simona Stolnicu1*, Enoe Quiñonez2, Monica Boros1, Claudiu Molnar3, Isabel Dulcey2 and Francisco F Nogales2

Author affiliations

1 Department of Pathology, University of Medicine and Pharmacy, Str. Gh. Marinescu nr 38, Targu Mures, Romania

2 San Cecilio University Hospital, Avenida Madrid 11, Granada, Spain

3 Department of Gynecology, University of Medicine and Pharmacy, Str. Gh. Marinescu nr 38, Targu Mures, Romania

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Citation and License

Diagnostic Pathology 2013, 8:162  doi:10.1186/1746-1596-8-162

Published: 25 September 2013


A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary lining, that expressed cytokeratins 7, 5/6 and calretinin as well as nuclear WT-1 and apical membrane staining for thrombomodulin, podoplanin D2-40 and HBME-1. In contrast, lining cells were CD68 negative. Foamy cell change has been reported in isolated cases as solid cords but not as a diffuse change in the mesothelial papillary lining. This phenomenon prompts differential diagnoses with abdominal and renal papillary clear cell tumours, which were discarded after a characteristic mesothelial immunophenotype was demonstrated.

Virtual slides

The virtual slide(s) for this article can be found here: webcite.

Mesothelioma; Papillary; Foamy cell change; Immunohistochemistry