Case report: Papillary mesothelioma of the peritoneum with foamy cell lining
1 Department of Pathology, University of Medicine and Pharmacy, Str. Gh. Marinescu nr 38, Targu Mures, Romania
2 San Cecilio University Hospital, Avenida Madrid 11, Granada, Spain
3 Department of Gynecology, University of Medicine and Pharmacy, Str. Gh. Marinescu nr 38, Targu Mures, Romania
Diagnostic Pathology 2013, 8:162 doi:10.1186/1746-1596-8-162Published: 25 September 2013
A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary lining, that expressed cytokeratins 7, 5/6 and calretinin as well as nuclear WT-1 and apical membrane staining for thrombomodulin, podoplanin D2-40 and HBME-1. In contrast, lining cells were CD68 negative. Foamy cell change has been reported in isolated cases as solid cords but not as a diffuse change in the mesothelial papillary lining. This phenomenon prompts differential diagnoses with abdominal and renal papillary clear cell tumours, which were discarded after a characteristic mesothelial immunophenotype was demonstrated.
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