Table 2

Characteristics of microRNAs that were significantly up- or down-regulated in pediatric brain tumors
MicroRNA P-value FDR Fold change Genomic location Strand Region
Up-regulated microRNAs
hsa-miR-363* 0.007497 0.010704 10.427700 ChrX: 133303408-133303482 - Intergenic
hsa-miR-181b 0.000527 0.002259 9.631896 Chr1: 198828002-198828111 - Intron
hsa-miR-21 0.003809 0.008158 6.844031 Chr17: 57918627–57918698 + Intergenic
hsa-miR-361-5p 0.000356 0.001831 6.274443 ChrX: 85158641-85158712 - Intron
hsa-miR-1321 0.000636 0.002333 5.102661 ChrX: 85090785-85090863 + Intergenic
hsa-miR-1259 0.000025 0.000650 4.581317 Chr20: 47896847-47896957 + Intron
hsa-miR-222 0.023138 0.018584 3.929640 ChrX: 45606421-45606530 - Intergenic
hsa-miR-92b 0.001809 0.005165 3.837460 ChrX: 85090785-85090863 + Intergenic
hsa-miR-1274b 0.027961 0.020354 3.745325 Chr19: 58024375-58024441 - Intergenic
hsa-miR-129-3p 0.033490 0.021517 3.154050 Chr7: 127847925-127847996 + Intergenic
hsa-miR-1827 0.015657 0.015330 2.974803 Chr12: 100583662-100583727 + Intergenic
hsa-miR-125b-1* 0.009024 0.011043 2.731521 Chr11: 121970465-121970552 - Intron
hsa-miR-149* 0.041545 0.023727 2.409994 Chr2: 241395418-241395506 + Intron
hsa-miR-760 0.003237 0.007563 2.151964 Chr1: 94312388-94312467 + Intergenic
hsa-miR-424* 0.032166 0.021374 2.039437 ChrX: 133680644-133680741 - Exon
hsa-miR-151-3p 0.013972 0.014363 1.884168 Chr8: 141742663-141742752 - Intron
hsa-miR-193a-5p 0.023719 0.018584 1.830744 Chr17: 29887015-29887102 + Intergenic
hsa-miR-513b 0.047111 0.025222 1.777760 ChrX: 146280562-146280645 - Intergenic
hsa-miR-1224-5p 0.036530 0.022353 1.771082 Chr3: 183959193-183959277 + Intron
hsa-miR-1308 0.039140 0.023393 1.737868 ChrX: 22080259-22080312 - Intergenic
hsa-miR-423-5p 0.020774 0.018410 1.689889 Chr17: 28444097-28444190 + Intron
hsa-miR-28-3p 0.017516 0.016077 1.527087 Chr3: 188406569-188406654 + Intron
hsa-miR-24 0.032436 0.021374 1.472878 Chr9: 97848303-97848370 + Intron
Down-regulated microRNAs
hsa-miR-128 0.000356 0.001831 0.193099 Chr2: 136422967-136423048 + Intron
hsa-miR-885-5p 0.006532 0.009875 0.266100 Chr3: 10436173-10436246 - Intron
hsa-miR-99b 0.002762 0.005834 0.295771 Chr19: 52195865-52195934 + Intron
hsa-miR-204 0.011402 0.012740 0.317649 Chr9: 73424891-73425000 - Intron
hsa-miR-1296 0.006368 0.009875 0.351976 Chr10: 65132717-65132808 - Intron
hsa-miR-455-3p 0.012976 0.013895 0.361298 Chr9: 116971714-116971809 + Intron
hsa-miR-486-5p 0.006404 0.009875 0.379200 Chr8: 41517959-41518026 - Intron
hsa-miR-218 0.028405 0.020354 0.382556 Chr4: 20529898-20530007 + Intron
hsa-miR-192 0.009599 0.011213 0.411599 Chr11: 64658609–64658718 - Intergenic
hsa-miR-323-3p 0.042741 0.023879 0.510200 Chr14: 101492069-101492154 + Intergenic
hsa-miR-331-3p 0.016105 0.015330 0.515895 Chr12: 95702196-95702289 + Intergenic
hsa-miR-769-3p 0.023862 0.018584 0.530823 Chr19: 46522190-46522307 + Intergenic
hsa-miR-181c 0.021556 0.018466 0.540432 Chr19: 13985513-13985622 + Intergenic
hsa-miR-342-3p 0.008581 0.011027 0.544354 Chr14: 100575992-100576090 + Intron
hsa-miR-484 0.005505 0.009875 0.566546 Chr16: 15737151-15737229 + 3’ UTR
hsa-miR-107 0.028512 0.020354 0.609175 Chr10: 91352504-91352584 - Intron
hsa-miR-26a 0.034746 0.021780 0.641470 Chr3: 38010895-38010971 + Intron

The version of human genome reference assemble used in the study was GRCh37/hg19. * represents the opposite arm of the miRNA precursor.

Liu et al.

Liu et al. Diagnostic Pathology 2013 8:158   doi:10.1186/1746-1596-8-158

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