Immunohistochemical staining of specimens from representative patients with FL (original magnification ×400). (A) Strong cytoplasmic expression of CD10 in a patient with low-grade FL. (E) Tumor cells are negative for CD10 in a patient with high grade FL. (B, C) Weak to negative nuclear expression of BCL6 and MUM1 in a patient with low-grade FL. (F, G) Partial positivity of tumor cells for BCL6 and MUM1 in a patient with high-grade FL. (D) BCL2 protein is expressed with consistent high intensity in the neoplastic cells in low-grade FL. (H) BCL2 protein is expressed with inconsistent median to week intensity in high-grade FL, and expressed negatively in some large transformed cells.
Zhang et al. Diagnostic Pathology 2013 8:154 doi:10.1186/1746-1596-8-154