FISH analysis of t(14;18) (q32;q21) translocation in representative patients with FL (original magnification ×40). (A) A patients with low-grade FL. (B) A patients with high-grade FL. The dual-fusion and dual color IGH/BCL2 probe was used. The expected pattern in a normal nucleus is the two orange, two green signal pattern (2O2G). Fusion signals (yellow arrows) represent fusion genes. In a nucleus harboring a t(14;18), the most common pattern is 1O1G2F.
Zhang et al. Diagnostic Pathology 2013 8:154 doi:10.1186/1746-1596-8-154