Table 1

Histopathological characteristics of neuroendocrine carcinomas of the small intestine[5]
Histotype Mitoses Ki67 index Nuclear atypia Necrosis Immunoreactivity
Well differentiated (G1- carcinoids) < 2/10 HPF < 2% Absent Absent Synaptophysin (+)
Chromogranin A (+)
Moderately differentiated (G2) 2–20/10 HPF 3-20% May be present May be present Synaptophysin (+)
Chromogranin A (+)
Poorly differentiated (G3 - neuroendocrine carcinoma) > 20/10 HPF > 20% Usually present Usually present Synaptophysin (+)
Chromogranin A (−/+)

Fiori et al.

Fiori et al. Diagnostic Pathology 2013 8:148   doi:10.1186/1746-1596-8-148

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