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Hepatic pseudocystic metastasis of well-differentiated ileal neuroendocrine tumor: a case report with review of the literature

Stefano Fiori1, Alessandro Del Gobbo1*, Gabriella Gaudioso1, Lucio Caccamo2, Sara Massironi3, Federica Cavalcoli3, Silvano Bosari14 and Stefano Ferrero15

Author affiliations

1 Division of Pathology, Fondazione IRCCS “Ca’ Granda” - Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milano 20100, Italy

2 Liver Transplant Unit, Fondazione IRCCS “Ca’ Granda” Ospedale Maggiore Policlinico, Milan, Italy

3 Gastroenterology Unit II, Fondazione IRCCS “Ca’ Granda” Ospedale Maggiore Policlinico, Milan, Italy

4 Department of Clinical/Surgical Pathophysiology and Organ Transplant, University of Milan Medical School, Milan, Italy

5 Department of Biomedical, Surgical and Dental Sciences, University of Milan Medical School, Milan, Italy

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Citation and License

Diagnostic Pathology 2013, 8:148  doi:10.1186/1746-1596-8-148

Published: 13 September 2013


Imaging appearance of cyst-like changes is most frequently described in primary neuroendocrine lesions, especially pancreatic NETs.

The imaging finding of a pseudocystic lesion of the liver puts in differential diagnosis many pathologies such as infectious diseases, simple biliary cysts up to biliary cystadenomas and eventually to primary or metastatic malignancies.

Primary or metastatic hepatic malignancies with pseudocystic aspects are rare, and a pseudocystic aspect is reported only after neo-adjuvant treatment.

Liver metastasis of untreated neuroendocrine tumors are usually solid and, to our knowledge, only two cases of neuroendocrine cystic hepatic metastases of ileal atypical carcinoids have been reported so far.

We present a case of a 67 years old man with synchronous finding of an untreated hepatic pseudocystic lesion and an ileal mass histologically diagnosed as a well differentiated (G1) neuroendocrine tumor.

The virtual slides for this article can be found here: webcite.

Pseudocystic metastasis; Neuroendocrine tumor; Hepatic malignancies