Table 2

Genetic and immunohistochemical characteristics of 11 cases of inflammatory myofibroblastic tumor with RANBP2-ALK gene fusion
Case Genetic features Immunohistochemical features
RANBP2toALKfusion point Detection techniques ALK Desmin SMA Caldesmin CD30 CK EMA S100
1 Exon 18 to exon 20 RT-PCR, FISH NM+ / / / / / / /
2 Exon 18 to exon 20 RT-PCR, FISH NM+ / / / / / / /
3 Exon 19 to exon 20* RT-PCR, FISH CP+ + + - / + / -
4 Exon 18 to exon 20 RT-PCR NM+ - - / - - / -
5 Exon 18 to exon 20 RT-PCR NM+ + - / / - / /
6 Exon 18 to exon 20 RT-PCR NM+ + - - + - - -
7 Exon 18 to exon 20 RT-PCR NM+ + / - + / / -
8 Exon 18 to exon 20 RT-PCR NM+ + + - + - / -
9 Unknown FISH CP+ + - / - + / -
10 Unknown FISH NM+ + + - + - - -
11 Exon 18 to exon 20 RT-PCR, FISH NM+ + + - + - - -
Total / / 100% (11/11) 89% (8/9) 50% (4/8) 0% (0/6) 71% (5/7) 25% (2/8) 0% (0/3) 0% (0/8)

NM nuclear membrane, CP cytoplasm.

*Reference 7 stated that the fusion point was exon 19 of RANBP2 to exon 20 of ALK, while Figure 2 in the paper indicated that the actual fusion location was exon 18 of RANBP2 to exon 20 of ALK.

Li et al.

Li et al. Diagnostic Pathology 2013 8:147   doi:10.1186/1746-1596-8-147

Open Data