Immunohistochemistry features of inflammatory myofibroblastic tumor. The tumor cells showed nuclear membranous ALK immunostaining (A), cytomembranous CD30 immunostaining (B), and cytoplasmic desmin immunostaining (C) (A and B, 400× original magnification; C, 200× original magnification). (D) Interphase fluorescence in situ hybridization (FISH) revealed 1 fused signal (arrow) in the tumor nucleus, indicating the presence of RANBP2-ALK translocation. One separate orange signal and 1 separate green signal indicated a normal ALK and a normal RANBP2 locus, respectively (1000× original magnification).
Li et al. Diagnostic Pathology 2013 8:147 doi:10.1186/1746-1596-8-147