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Open Access Case Report

Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study

Guang-Zhi Yang1*, Jing Li1, Hua Jin2 and Hua-Ye Ding1

Author affiliations

1 Department of Pathology, The General Hospital of Beijing Military Command, Beijing, 100700, China

2 Department of Pathology, The 263rd Hospital of PLA, Beijing, 101149, China

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Citation and License

Diagnostic Pathology 2013, 8:14  doi:10.1186/1746-1596-8-14

Published: 28 January 2013

Abstract

Mammary sarcoma is extremely rare and the diagnosis is established only after metaplastic carcinomas and malignant phyllodes tumours are excluded. A rare case of not otherwise specified-type sarcoma with CD10 expression in the left breast in a 45-year-old female was presented. It was a high-grade tumour composed of spindle cells histologically. The immunohistochemical results showed that CD10, vimentin and EGFR were positive diffusely and SMA presented focally, whereas epithelial markers and other myoepithelial or myogenic markers were all negative. The electron microscope investigation demonstrated fibroblast-like features. The exact entity of the tumour remains to be studied because it resembles undifferentiated sarcoma or sarcomatoid metaplastic carcinoma to some degree, as well as high-grade malignant phyllodes tumour in particular.

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9019879588725702 webcite

Keywords:
Sarcoma; Breast; CD10; Undifferentiated sarcoma; Phyllodes tumour; Metaplastic carcinoma