Punch biopsy from the left neck with involvement by HL. 1a and 1b: Hemotoxylin and Eosin stain (20× and 100×). There is an atypical infiltrate involving the entire dermis with scattered larger cells. A grenz-zone is between the infiltrate and the epidermis. 1c – 1f: Hemotoxylin and Eosin stain (200× and 400×). The infiltrate is composed predominantly of small lymphocytes and abundant histiocytes in the background. Several large cells, some of which are binucleated and show prominent nucleoli (compatible with Reed-Sternberg cells and RS variants) are seen. In addition, scattered neutrophils are also present. Atypical mitoses can be easily detected.
Gru and Lu Diagnostic Pathology 2013 8:135 doi:10.1186/1746-1596-8-135