Immunohistochemical demonstration of claudin protein expression in human gastric cancer and adjacent tissue. Claudins were expressed in the cell cytoplasm and membrane. (A), claudin-2 was highly expressed in epithelial cells adjacent to gastric cancer but was expressed at low levels in cancer tissue itself (B). (C), the strong expression of claudin-6 in tissue adjacent to human gastric cancer compared to low expression of claudin-6 in human gastric cancer tissue (D). (E), low claudin-11 expression was detected in tissue adjacent to human gastric cancer compared with high claudin-11 expression in human gastric cancer tissue (F) (400×).
Lin et al. Diagnostic Pathology 2013 8:133 doi:10.1186/1746-1596-8-133