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The distinct expression patterns of claudin-2, -6, and −11 between human gastric neoplasms and adjacent non-neoplastic tissues

Zhe Lin2, Xiaowei Zhang1, Zhijing Liu1, Qihui Liu1, Liping Wang1, Yan Lu1, Yuanyuan Liu1, Min Wang1, Minlan Yang1, Xiangshu Jin1 and Chengshi Quan1*

Author Affiliations

1 The Key Laboratory of Pathobiology, Ministry of Education, Bethune Medical College, Jilin University, Changchun, Jilin, China

2 Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China

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Diagnostic Pathology 2013, 8:133  doi:10.1186/1746-1596-8-133

Published: 6 August 2013



Cancers have a multifactorial etiology a part of which is genetic. Recent data indicate that expression of the tight junction claudin proteins is involved in the etiology and progression of cancer.


To explore the correlations of the tight junction proteins claudin-2,-6, and −11 in the pathogenesis and clinical behavior of gastric cancer, 40 gastric cancer tissues and 28 samples of non-neoplastic tissues adjacent to the tumors were examined for expression of claudin-2,-6, and −11 by streptavidin-perosidase immunohistochemical staining method.


The positive expression rates of claudin-2 in gastric cancer tissues and adjacent tissues were 25% and 68% respectively (P < 0.001). The positive expression rates of claudin-6 in gastric cancer tissues and adjacent tissues were 55% and 79% respectively (P = 0.045 < 0.05). In contrast, the positive expression rates of claudin-11 in gastric cancer tissues and gastric cancer adjacent tissues were 80% and 46% (P = 0.004 < 0.01). Thus in our study, the expression of claudin-2, and claudin-6 was down regulated in gastric cancer tissue while the expression of claudin-11 was up regulated. Correlations between claudin expression and clinical behavior were not observed.


Our study provides the first evidence that claudin-2,-6, and −11 protein expression varies between human gastric cancers and adjacent non-neoplastic tissues.

Virtual slides

The virtual slide(s) for this article can be found here: webcite

Gastric cancer; Tight junctions; Claudin-2; Claudin-6; Claudin-11; Immunohistochemistry