The correlation between the expression of MMP-9 mRNA and degree of mononuclear cells infiltration in allografts. MMP-9 mRNA level of allografts was demonstrated by MMP-9 mRNA/β-actin mRNA ratio, the degree of interstitial mononuclear cell infiltration was evaluated according to Banff Criteria, as follow, 0 = No or trivial interstitial inflammation; 1 = up to 25% of parenchyma inflamed; 2 = 26% to 50% parenchyma inflamed; 3 = > 50% parenchyma inflamed. The result of bivariate non-parameter correlation analysis demonstrated: the MMP-9 mRNA levels of allografts were correlated to the degrees of interstitial mononuclear cell infiltration. (P < 0.05, Spearman correlation coefficient was 0.653).
Gu et al. Diagnostic Pathology 2013 8:13 doi:10.1186/1746-1596-8-13