Table 2

Correlation between cytoplasmic CARM1 expression and the clinicopathologic characteristics of breast cancer patients
Clinicopathologic characteristics n Cytoplasmic CARM1 expression P
Negative or low expression (IHC score < 80) High or over expression (IHC score ≥ 80)
Age(y)
≤40 53 16 (30.2) 37 (69.8) 0.041
>40 194 89 (45.9) 105 (54.1)
Tumor size
≤2 cm 125 57 (45.6) 68 (54.4) 0.320
>2 cm 122 48 (39.3) 74 (60.7)
Tumor number
1 234 101 (43.2) 133 (56.8) 0.379
≥2 13 4 (30.8) 9 (69.2)
Grade
I&II 181 85 (47.0) 96 (53.0) 0.019
III 66 20 (30.3) 46 (69.7)
Lymph node metastasis
N0 127 48 (37.8) 79 (62.2) 0.123
N1, N2,N3 120 57 (47.5) 63 (52.5)
TNM stage
I 74 30 (40.5) 44 (59.5) 0.384
II 111 44 (39.6) 67 (60.4)
III 62 31 (50.0) 31 (50.0)
ER
negative 90 28 (31.1) 62 (68.9) 0.006
positive 157 77 (49.0) 80 (51.0)
PR
negative 136 50 (36.8) 86 (63.2) 0.043
positive 111 55 (49.5) 56 (50.5)
HER2
negative 206 93 (45.1) 113 (54.9) 0.060
positive 41 12 (29.3) 29 (70.7)
Expression of K-i67
low (≤10%) 55 31 (56.4) 24 (43.6) 0.018
high (>10%) 192 74 (38.5) 118 (61.5)
Expression of P53
low 95 45 (47.4) 50 (53.6) 0.222
high 152 60 (39.5) 92 (60.5)

P value is the result of χ2 test in the same factor, and < 0.05 is considered statistically significant.

Cheng et al.

Cheng et al. Diagnostic Pathology 2013 8:129   doi:10.1186/1746-1596-8-129

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