The expression pattern of CARM1 in human invasive breast cancer (×400). A In positive samples, the expression of CARM1 in adenocarcinomas was considerably increased compared with the adjacent benign glandular epithelium (A and B). The increased expression was both nuclear and cytoplasmic (C), predominantly nuclear (D), or predominantly cytoplasmic (E). A representative negative case is shown (F). Asterisks indicate adenocarcinoma. Arrows indicate benign breast epithelium. B CARM1 expression was increased significantly in invasive breast cancer compared with benign epithelium (one-way ANOVA P < 0.001).
Cheng et al. Diagnostic Pathology 2013 8:129 doi:10.1186/1746-1596-8-129