Email updates

Keep up to date with the latest news and content from Diagnostic Pathology and BioMed Central.

Open Access Highly Accessed Research

The association between the PPARγ2 Pro12Ala polymorphism and nephropathy susceptibility in type 2 diabetes: a meta-analysis based on 9,176 subjects

Lei Wang1*, Zan Teng2, Shuang Cai3, Difei Wang4, Xin Zhao1 and Kai Yu1

Author affiliations

1 Department of Gerontology and Geriatrics, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001 China

2 Department of Medical Oncology, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001 China

3 Department of Pharmacy, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001, China

4 Department of Endocrinology and Metabolism, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001, China

For all author emails, please log on.

Citation and License

Diagnostic Pathology 2013, 8:118  doi:10.1186/1746-1596-8-118

Published: 15 July 2013

Abstract

Background

The polymorphism Pro12Ala in peroxisome proliferator-activated receptor­γ2 gene (PPARγ2) has been reported to be associated with diabetic nephropathy (DN) in some studies, though the results remain inconclusive. To explore this relationship between PPARγ2 Pro12Ala polymorphism and the susceptibility for DN, a cumulative meta-analysis was performed in this study.

Method

PubMed, Medline, Embase and Web of Science databases have been systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results

18 studies were included in this meta-analysis, involving 3,361 cases and 5,815 controls. The PPARγ2 Ala12 allele was significantly associated with decreased risk of DN based on dominant model (OR=0.778; 95%CI=0.618–0.981; Pheterogeneity=0.008; P=0.034). In the stratified analysis by ethnicity, significantly decreased risks were found among Caucasians for dominant model (OR=0.674; 95%CI=0.500–0.909; Pheterogeneity=0.079; P=0.010), while there was no significant association was found in Asians.

Conclusions

The results from the present meta-analysis indicated that the Pro12Ala polymorphism in PPARγ2 gene is not a risk factor for DN in type 2 diabetes (T2D). Further large and well-designed studies are needed to confirm this conclusion.

Virtual slides

The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7491348341027320 webcite.

Keywords:
PPARγ2; Meta-analysis; Diabetic nephropathy; Polymorphisms