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Open Access Case Report

Lipofibroadenoma of the thymus: a case report

Guimei Qu1, Guohua Yu1*, Qian Zhang2, Junjie Ma3 and Xiaolei Wang3

Author Affiliations

1 Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, No.20, Yuhuangding East Road, Yantai 264000, PR China

2 Department of Pathology, Binzhou Medical University, No.346, Guanhai Road, Yantai 264003, China

3 Department of Hametolgoy, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, No.20, Yuhuangding East Road, Yantai 264000, China

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Diagnostic Pathology 2013, 8:117  doi:10.1186/1746-1596-8-117

Published: 15 July 2013

Abstract

We observed an unusual case of Lipofibroadenoma (LFA) in the anterior mediastinum with a 21-year-old man, who was detected with a mass on a chest X-ray scan for one month. Thymothymectomy was then performed and the mass was excised completely, in which the tumor was histologically composed of epithelial cells, lymphocytes, mature adipose and fibrous tissue. Within the tumor, the fat cells was distributed singly or multifocally under the ground of fibro tissue with hyaline degeneration, and the epithelial cells were arranged as crack structure with lymphocytes infiltrated sparsely. By immunohistochemical staining assay, the epithelial cells were positive for AE1/AE3 and CK19, and the lymphocytes were CD3 and CD20 positive. Based on the histological characters, a diagnosis of LFA was made, and the total follow-up period was determined to be forty six months. The final repeated CT scan revealed no recurring or residual lesions were detected during the post-surgical course.

Virtual slide

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1500429801911703 webcite

Keywords:
Lipofibroadenoma; Thymic tumor