Table 2

Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis
Variables No. of studies OR (95% CI) Ph P OR (95% CI) Ph P OR (95% CI) Ph P
Gln/Gln vs Lys/Lys Gln/Gln vs Gln/Lys Gln/Lys vs Lys/Lys
Total 9 1.352 (1.088 1.681) 0.000 0.00 1.354 (1.085 1.688) 0.001 0.007 1.017 (0.932 1.109) 0.592 0.712
Ethnicity
Caucasian 3 1.240 (0.927 1.658) 0.002 0.148 1.184 (0.913 1.536) 0.006 0.203 1.041 (0.938 1.155) 0.278 0.448
African 3 1.758 (1.097 2.819) 0.373 0.019 1.800 (0.969 3.342) 0.196 0.063 0.955 (0.680 1.341) 0.575 0.791
Asian 2 1.476 (1.110 1.962) 0.554 0.007 1.586 (1.105 2.276) 0.256 0.012 0.962 (0.802 1.154) 0.655 0.677
Source of controls
HB 5 1.225 (0.967 1.551) 0.009 0.093 1.233 (0.969 1.570) 0.88 0.088 1.017 (0.924 1.120) 0.382 0.728
PB 3 1.854 (1.338 2.569) 0.958 0.000 1.806 (1.310 2.491) 0.896 0.000 1.013 (0.823 1.247) 0.678 0.900
Variables No. of studies OR (95% CI) Ph P OR (95% CI) Ph P OR (95% CI) Ph P
Lys/Lys vs Gln/Gln + Gln/Lys (dominant model) Gln/Gln vs Gln/Lys + Lys/Lys (recessive model) Gln allele vs Lys allele
Total 9 0.945 (0.867 1.029) 0.397 0.194 1.362 (1.099 1.688) 0.18 0.18 1.109 (1.013 1.214) 0.019 0.024
Ethnicity
Caucasian 3 0.940 (0.814 1.085) 0.086 0.397 1.219 (0.934 1.591) 0.002 0.145 1.097 (0.960 1.254) 0.003 0.175
African 3 0.890 (0.649 1.220) 0.948 0.468 1.781 (1.057 3.002) 0.241 0.030 1.258 (1.001 1.579) 0.546 0.049
Asian 2 0.954 (0.803 1.133) 0.846 0.590 1.489 (1.130 1.962) 0.357 0.005 1.123 (0.989 1.275) 0.996 0.073
Source of controls
HB 5 0.962 (0.865 1.070) 0.264 0.480 1.239 (0.982 1.563) 0.003 0.071 1.078 (0.971 1.197) 0.021 0.160
PB 3 0.874 (0.718 1.065) 0.655 0.183 1.824 (1.343 2.477) 0.956 0.000 1.233 (1.067 1.423) 0.749 0CPA004

OR Odds Ratio, CL Confidence Interval, Ph P value of heterogeneity.

Dou et al.

Dou et al. Diagnostic Pathology 2013 8:112   doi:10.1186/1746-1596-8-112

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