Table 2

Relationship between advanced gastric cancer pathology TIMP3 methylation and its protein expression level
Index n TIMP3 promoter methylation TIMP3 protein tumor size
Tumor size (cm)   <5 5 3 (60.0) 1 (20.0)
  5 − 10 45 42 (93.3) 18 (40.0)
  >10 8 7 (87.5) 2 (25.0)
General types   Borr.2 12 10 (83.3) 4 (33.3)
  Borr.3 37 33 (89.2) 15 (40.5)
  Borr.4 9 9 (100.0) 2 (22.2)
Histological differentiation Differentiated 44 39 (88.6) 17 (38.6)
Undifferentiated 14 13 (92.9) 4 (28.6)
Growth pattern Clumps + nested 27 21 (77.8) 15 (55.6)
Diffuse-like 31 31 (100.0) b 6 (19.4) b
Lymph node metastasis   <7 36 30 (83.3) 17 (47.2)
  ≥7 22 22 (100.0) a 4 (18.2) a
Infiltration Submucosal muscularis 6 3 (50.0) 1 (16.7)
Subserosal 23 21 (91.3) a 9 (39.1)
Serosa 29 28 (96.6) 11 (37.9)

aP < 0.05, bP < 0.01.

Guan et al.

Guan et al. Diagnostic Pathology 2013 8:110   doi:10.1186/1746-1596-8-110

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