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Open Access Case Report

Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report

Metka Volavšek1*, Margareta Strojan-Fležar1 and Gregor Mikuz2

Author affiliations

1 Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia

2 Department of Pathology, University of Innsbruck, Innsbruck, Austria

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Citation and License

Diagnostic Pathology 2013, 8:108  doi:10.1186/1746-1596-8-108

Published: 2 July 2013

Abstract

Thyroid-like follicular carcinoma of the kidney (TLFC), a rare neoplasm with low malignant potential, is histologically similar to primary thyroid follicular carcinoma, but characteristically lacks thyroid immunohistochemical markers. We report a case of 34-year old patient with nephrolithiasis. Ultrasound revealed hepatorenal cysts consistent with adult type polycystic kidney disease (ATPKD) and a cytologically confirmed left kidney tumor. Nephrectomy specimen contained sharply demarcated lesion of unusual morphology. Tubular and cystic structures lined by mostly cuboidal cells and filled with amorphous eosinophillic material, reminiscent of follicular carcinoma of the thyroid gland, were diagnostic for TLFC. Thyroid markers were negative. To our knowledge this is the first report of TFLC associated to ATPKD. Brief review of previously published TFLCs, possible relationship between entities and differential diagnosis are discussed.

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8067946569612694 webcite

Keywords:
Renal cell carcinoma; Thyroid-like follicular carcinoma; Pathology-cytology; Immunohistochemistry; Polycystic kidney disease