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Reduced expression of miR-22 in gastric cancer is related to clinicopathologic characteristics or patient prognosis

Weibin Wang1, Fujun Li1*, Yong Zhang2, Yanyang Tu3, Qi Yang3 and Xingchun Gao3

Author affiliations

1 Department of General Surgery, The 323th Hospital of PLA, Xi’an 710054, China

2 Authorities outpatient Department of Lanzhou Military region, Lanzhou 730000, China

3 Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an City 710038, P.R. China

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Citation and License

Diagnostic Pathology 2013, 8:102  doi:10.1186/1746-1596-8-102

Published: 21 June 2013



Involvements of microRNA-22 (miR-22) in cancer development have attracted much attention, but its role in tumorigenesis of gastric cancer is still largely unknown. Therefore, the aim of this study was to investigate the expression patterns and clinical implications of miR-22 in gastric cancer.


Quantitative RT-PCR was performed to evaluate the expression levels of miR-22 in 98 pairs of gastric cancer and normal adjacent mucosa.


Compared with normal adjacent mucosa, miR-22 expression was significantly downregulated in gastric cancer tissues (P < 0.001). Of 98 patients with gastric cancer, 58 (59.2%) were placed in the low miR-22 expression group and 40 (40.8%) were placed in the high miR-22 expression group. In addition, tumors with low miR-22 expression had greater extent of lymph node metastasis (P = 0.02) and distant metastasis (P = 0.01), and were at a worse stage (P = 0.01) than the tumors with high miR-22 expression. Moreover, the gastric cancer patients with low miR-22 expression had shorter overall survival than those with high miR-22 expression (P = 0.03). MiR-22, determined by multivariate analysis, was an independent prognostic factor for patients with gastric cancer.


Our data offer the convincing evidence that the reduced expression of miR-22 was significantly associated with malignant development of gastric cancer and may be a novel prognostic marker of this disease. miR-22 might have potentials in the application of cancer therapy for patients with gastric cancer.

MicroRNA-22; Gastric cancer; Prognosis; Quantitative RT-PCR