Table 3

Cox proportional hazards model for colorectal cancer specific survival related to MSI screening status and beta-catenin overexpression in the full cohort and in stage III-IV disease
Full cohort Stage III-IV disease
HR(95% CI) p-value N(events) HR(95% CI) p-value n(events)
Univariable Univariable
MSS 1,00 0,010** 438(157) 1,00 0,036* 201(122)
MSI 0,50(0,29-0,84) 77(15) 0,46(0,23-0,95) 23(8)
Multivariable Multivariable
MSS 1,00 0,010* 389(137) 1,00 0,011* 185(107)
MSI 0,46(0,25-0,84) 73(13) 0,33(0,14-0,78) 20(6)
Univariable Univariable
Bata-catenin low 1,00 0,056 251(96) 1,00 0,063 112(72)
Bata-catenin High 0,75(0,56-1,01) 276(86) 0,73(0,52-1,02) 122(66)
Multivariable Multivariable
Bata-catenin low 1,00 0,031* 223(80) 1,00 0,036* 98(60)
Bata-catenin High 0,70(0,51-0,97) 247(75) 0,67(0,46-0,97) 113(57)

*Significant at the 0.05 level. **Significant at the 0.01 level. P-value from multivariable analysis adjusted for age (>/<=75 years), gender, T-stage (I-II, III, IV), N-stage (0,1,2), M-stage (0, 1), differentiation grade (high-intermediate vs low) and vascular invasion (+/−/unknown). Beta-catenin low = beta-catenin score 0–2. Beta catenin high = beta-catenin score 3–5.

Wangefjord et al.

Wangefjord et al. Diagnostic Pathology 2013 8:10   doi:10.1186/1746-1596-8-10

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