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Open Access Highly Accessed Case Report

Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report

Hacer Haltas14*, Reyhan Bayrak1, Sibel Yenidunya1, Dilek Kosehan2, Meral Sen3 and Kayihan Akin2

Author Affiliations

1 Department of Pathology, Fatih University School of Medicine, No:57 06510, Ankara, Turkey

2 Department of Radiology, Fatih University School of Medicine, No:57 06510, Ankara, Turkey

3 Department of General Surgery, Fatih University School of Medicine, No:57 06510, Ankara, Turkey

4 Fatih Üniversitesi Tıp Fakültesi, Alparslan Türkeş cad, No:57 06510, Ankara, Turkey

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Diagnostic Pathology 2012, 7:91  doi:10.1186/1746-1596-7-91

Published: 6 August 2012


The differences between invasive lobular and ductal carcinomas affect the diagnostic and therapeutic management for patients with breast cancer. In most cases, this can be accomplished because of distinct histomorphologic features. However, occasionally, this task may become quite difficult, in particular when dealing with the variants of infiltrating lobular carcinoma. Lobular carcinoma has been considered a variant of mucin-secreting carcinoma with only intracytoplasmic mucin. The presence of extracellular mucin is a feature of ductal carcinoma. Herein is presented a case of lobular carcinoma with extracellular and intracellular mucin in a 43-year-old female patient, and confirmed by immunohistochemistry. Up to the present, infiltrating lobular carcinoma displaying extracellular mucin has not been described in the literature except two case.

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