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Open Access Open Badges Case Report

A noninvasive mucinous cystic neoplasm with intermediate-grade dysplasia of the pancreas and extensive squamous metaplasia: a case report with clinicopathological correlation

Peifeng Li12, Yingmei Wang1, Qingqing Zhang3, Yixiong Liu1, Yang Lv1 and Zhe Wang1*

Author Affiliations

1 Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, Shaanxi, 710032, People's Republic of China

2 Department of Pathology, The General Hospital of Jinan Military Command, Ji’nan, China

3 Department of Hepatobiliary Surgery, Weifang People's Hospital, Weifang, China

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Diagnostic Pathology 2012, 7:89  doi:10.1186/1746-1596-7-89

Published: 31 July 2012


Squamous metaplasia presenting in noninvasive mucinous cystic neoplasm (MCN) of the pancreas is extremely rare. We described a case of 39-year-old Chinese female with a 5-year history of a slow growing mass in the left upper abdomen and an 18-month history of surgical incision exudation. The patient underwent cystojejunostomy, laparotomy and distal pancreatectomy consecutively because of the initial diagnosis of “pancreatic cyst”. The histological section showed columnar mucin-producing epithelium formed small papillary projections and extensively visible squamous metaplasia. Therefore the diagnosis of “noninvasive MCN with intermediate-grade dysplasia of the pancreas and extensive squamous metaplasia” was made finally. The squamous component of the pancreas may be derived from pluripotent stem cells, and may be in association with cystojejunostomy.

The virtual slide(s) for this article can be found here webcite

Mucinous cystic neoplasm; Squamous metaplasia; Pancreas; Immunohistochemistry