Table 1

Demographic and Clinic-pathological features of the subjects under study
Variable CTR COPD LC
(N = 33) (N = 23) (N = 26)
Age (y) 55 (23–82) 2 66 (41–85)2 66 (25–87)2
Male (%) 15 (45) 10 (44) 18 (69)
Female (%) 18 (54) 13 (56) 8 (31)
Smoking history (%)
Never smoker 33 (100) 0 (0) 8 (31)
Ex-smokers 0 (0) 7 (30) 7 (27)
Smokers 0 (0) 16 (70) 11 (42)
Smoking Frequency (%)
< 35 cigarette pack 0 18 (78) 10 (56)
≥ 35 cigarette pack 0 5 (22) 8 (44)
COPD by Spirometry (%)
GOLD 0 - 4 (17) 7 (27)
GOLD 1 - 5 (22) 1 (4)
GOLD 2 - 5 (22) 12 (46)
GOLD 3 - 8 (35) 5 (19)
GOLD 4 1 (4) 1 (4)
Histology (%) - -
NSCLCs - - 25 (96)
-SCC - - 6 (23)
-AD - - 6 (23)
-LCLC - - 13 (50)
SCLC 1 (100)
Cytological analysis (%)
Normal cells 29 (88)3 5 (22) 8 (31)
Inflammatory cells 4 (12) 18 (78) 3 (12)
Atypia cellular4 - - 6 (23)
CIS (cancer cells)5 - - 12 (46)
Sputum DNA (ng/mL) 2.75 (0.00-4.95)6 15.95 (8.25-20.35)7 20.35 (4.95-28.60)

1 Statistical comparisons are between cases (COPD, LC) and CTR.

2 Median (minimum and maximum).

3 p < 0.05 compared with COPD.

4 Atypia cells (was classified from mild to severe.

5 CIS = Carcinoma in situ.

6 p < 0.0001 compared with COPD and LC.

7p > 0.05 compared with LC.

Guzmán et al.

Guzmán et al. Diagnostic Pathology 2012 7:87   doi:10.1186/1746-1596-7-87

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