Table 1

Associations between MCM3 expression and clinicopathological factors
MCM3 expression
Factor Low High P
n(%) 133 (59.4) 91 (40.6)
Age (continuous) 0.858
Mean 67.36 67.25
Median 69.00 69.00
Range 46-81 47-83
Location 0.893
Dorsal trunk 33 (26.0) 23 (25.6)
Frontal trunk 16 (12.6) 12 (13.3)
Arms 22 (17.3) 18 (20.0)
Legs 37 (29.1) 23 (25.6)
Head and neck 19 (15.0) 14 (15.6)
Unknown 6 1
Histological subtype 0.003
SSM 89 (66.9) 53 (58.9)
LMM 18 (13.5) 5 (5.6)
NMM 23 (17.3) 30 (33.3)
Other 3 (2.3) 2 (2.2)
Unknown 1
Breslow thickness <0.001
Mean 1.48 1.94
Median 0.55 1.05
Range 0.08-40 0.15-14
Unknown 1 1
Breslow categories <0.001
≤ 1 mm 93 (70.5) 44 (48.9)
1.1-2.0 mm 19 (14.4) 15 (16.7)
2.1-4.0 mm 14 (10.6) 23 (25.6)
> 4.0 mm 6 (4.5) 8 (8.9)
Unknown 1 1
Clark level <0.001
II 58 (43.9) 19 (21.3)
III 58 (43.9) 39 (43.8)
IV-V 16 (12.1) 31 (34.8)
Unknown 1 2
Ulceration <0.001
No 122 (91.7) 67 (74.4)
Yes 11 (8.3) 23 (25.6)
Unknown 1
Clinical stage 0.003
1 108 (91.5) 50 (75.8)
2-4 10 (8.6) 16 (24.2)
Unknown 15 24
Vascular invasion 0.016
No 129 (97.0) 81 (89.0)
Yes 4 (3.0) 10 (11.0)
Mitotic count <0.001
0/mm2 87 (65.4) 27 (29.7)
> = 1/mm2 46 (34.6) 64 (70.3)
Lymphocytic infiltrate 0.463
None-mild 40 (30.5) 23 (25.6)
Moderate-brisk 93 (69.9) 67 (74.4)
Unknown 1
Ki67 expression 0.001
Low 100 (85.5) 58 (65.9)
High 17 (14.5) 30 (34.1)
Unknown 16 3
RBM3 expression 0.025
Low 46 (37.4) 48 (52.7)
High 77 (62.6) 43 (47.3)
Unknown 10 0

P-values refer to Mann Whitney U test for comparison of medians and Chi square test for X × 2 tables. The categories marked as unknown were not included in the analysis.

Low RBM3 expression corresponds to a nuclear staining intensity of negative to moderate and high expression corresponds to strong staining as previously described [12].

Nodin et al.

Nodin et al. Diagnostic Pathology 2012 7:82   doi:10.1186/1746-1596-7-82

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